I have a pair of 26" 1920x1200 monitors, and a 15.6" 1920x1080 laptop. When I use the laptop with the monitors, I set the laptop display to portrait and 150% scaling (ideally I'd like it to be 160% but can't do that). The other two monitors remain at 100% and it all works reasonably well.

Problem is, when the laptop is actually out and about, I can have DF set to the other profile which has it in landscape, but the scaling remains at 150% which is now incredibly annoying when the screen has to contain a lot more things and is a lot closer to my face.

So, any way to control the scaling with the DF monitor profiles?