My setup is not typical, and I have had random hanging/crashing with an open email to support.

In the mean time, since I'm still not convinced DisplayFusion is my issue, tonight I installed the latest chipset drivers for my motherboard, then booted into safe mode and used the AMD Radeon cleanup utility, then reinstalled my graphics driver. I decided to run a benchmark and compare it to one when I installed the two new graphics cards.

To my surprise, the two runs I did tonight (only changing one thing: closing DisplayFusion) show a lot different graphics benchmark. I am curious if this is expected behavior or not.

My setup is not normal with 12 QHD monitors.

Benchmark with DisplayFusion open (graphics score is 102%):
https://www.userbenchmark.com/UserRun/44693473

Versus this one with DisplayFusion closed (graphics score is 137%): https://www.userbenchmark.com/UserRun/44360269

EDIT:
I cannot repeat these low score for having DisplayFusion open. I did two more runs with it open, and the GPU benchmark is the high number 137%. I do wonder what was different on the test that got 102%...

DF Started as User:
https://www.userbenchmark.com/UserRun/44694526

DF Started as Admin:
https://www.userbenchmark.com/UserRun/44694697

Heaven Benchmark
DF ON 34.6, 872
DF OFF 34.3, 865

Temps were stabilized before starting each run, and pretty much everything was off on my laptop. Sample size of one, but probably worth considering since 34-35fps is what this old laptop has done on that benchmark for some time now.