When I click on a taskbar icon in Window #1 (my computer monitor), it opens the program in Window #2.

Once I have an instance of the application open, CTL+N works fine & opens the window in whatever screen is selected.

Notes:
- I have "Move newly opened application windows to the current monitor" selected.
- I think this may have been impacted by a recent update to Windows 10.

Any ideas?

Thanks!

Yes, Chrome. It appears the other shortcuts on the taskbar work properly (including MS Edge) so I think the issue is with the Chrome shortcut. FYI I'm on a HP Spectre running Win 10.

I've found a workaround but wanted to give you the information JIC.

The taskbar shortcut target: "C:\Program Files (x86)\Google\Chrome\Application\chrome.exe"

MY TESTING RESULTS
When no Chrome instances are open:
Selecting Chrome from the menu of Display 1 opens it in Display 1.
Selecting Chrome from the menu of Display 2 opens it in Display 2.
Selecting Chrome from the taskbar of Display 1 opens it in Display 2. <--the problem
Selecting Chrome from the taskbar of Display 2 opens it in Display 2.

When Chrome is open on Display 1:
Selecting Chrome from the menu of Display 2 opens it in Display 2.
Selecting Chrome from the taskbar of Display 2 opens it in Display 1. <--perhaps a clue

When Chrome is open on Display 2:
Selecting Chrome from the menu of Display 2 opens it in Display 2.
Selecting Chrome from the taskbar of Display 2 opens it in Display 1. <--perhaps a clue