OK so DF can have hotkeys assigned to Window Postion Profiles - my question is, can desktop shortcuts also be created to activate them, if so, then how is this done (I did try to find an answer to this, but couldn't find one)...

Thanks for any help

https://www.displayfusion.com/HelpGuide/DisplayFusionCommandLineTool/
In particular, you seem to want
Make a shortcut to the program on your desktop and add the command line args to the target.

THANK YOU SO MUCH, that worked - I should of known but I'm old and rusty