I use DisplayFusion on my laptop and most of the time I don't bother connecting it to my secondary display. It's during this time that I sometimes notice DisplayFusion (v3.0.4) spiking its CPU usage (around 50-60% on a 32-bit Vista machine).
The feature I'm looking for is an option for DisplayFusion to exit (or maybe prompt for exit) if it doesn't detect a second monitor. I really only use DisplayFusion for the multi-monitor taskbar, so I'd rather just have the program exit if there's no additional monitors for it work with.
I have made some improvements regarding CPU usage in the upcoming version 3.0.5. As for exiting immediately, I don't think I will do this as many people use it to manage their wallpaper on single-monitor systems as well.