Yesterday I updated to version 11.1 (from 11.0.5). At first, right after the update, seemingly nothing changed. Then after logging out and back into my user account, the desktop icons were all over the place. I restarted the PC, but the icons were still in the incorrect positions.
Now I've noticed that DisplayFusion does no longer remember icon positions at all. If I move my desktop icons (with DisplayFusion enabled), the new positions will be lost upon restarting the PC or just restarting DisplayFusion. Any ideas?

This is weird. I don't have any Desktop Icon profile (see screenshot), though I'm very certain that previously the icon position were managed by DisplayFusion (DF). Every time I exited DF all my icons were moved to other positions and everytime I started DF the position intended by me were restored. Also every time when logging into a user account the icons were moved at some point in the desktop loading progress. I installed version 11.05 again and the behaviour sadly did not change.
I've conducted some tests and the results are quite confusing to me. When I move icons while DF is running the new positions get lost upon exiting DF (kinda expected?). But also if I move the icons while DF is not running. E.g. I move some desktop icons while DF is closed. Then I start it - the icon positions do not change. However, if I exit DF again the old icon positions are restored. I did not install anything in the past few days, only uninstalled and I seriously doubt there is any connection to that. If I save an icon profile, restoring this profile does work however. I had DF Pro installed for literally years and icons were moved to the intended position upon logon. Now they are always at the same positions (all over the place) even if I tried to move them.
I appreciate any ideas.

Thanks for the suggestion and sorry for the delay. I did what you suggested and after disabeling the Multi-Monitor Taskbars the desktop icons are no longer moving upon exiting DF. The icons still move back to their original positions upon logout and re-login or device restart, though. If Multi-Monitor taskbars are enabled again the icons also move when exiting DF, as before.
I did reset all my settings from the Troubleshooting->Advanced tab. This did not change any behavoir. Then I uninstalled DF including all settings and preferences. Now the icons were always staying in the intended place, even upon re-login and restart.
I reinstalled DF and did not enable DF-Taskbars in the Welcome-screen (kept Windows Taskbars). Icons were still working fine. I enabled Multi-Monitor Taskbar (and DF-Taskbars) and the problem reoccured. I disabled Multi-Monitor taskbars and the problem still occured upon re-login or device restart. Enabled Windows taskbars from the windows settings and icons were working as intended again. So my current, a bit unsatisfactory, solution is to keep Windows taskbars enabled. I don't know what the exact issue is, but it has something to do with the DF taskbars I guess.