If I use Prevent Window Deactivation with World of Warcraft or Heroes of the Storm in full screen mode and then close, minimize, or open a window on my second monitor those windows will freeze, become slightly transparent and I can click through them as if they weren't there. If I close the game everything starts working normally.
Edit: I found the "Allow taskbar reloading while full screen applications are running" option. This seems to have fixed this issue.

For Diablo 3, the Lock/Unlock Mouse Cursor to Current Monitor function does not work for me.

For Hearthstone, every time I click on something on my second monitor the taskbar on the first monitor shows up over the game. Not a huge deal, but kind of annoying, and something I probably wouldn't want if I ever started streaming.

I don't know if you want me to create a new discussion for each issue, but I figured I'd start with everything.