Ever since I upgraded to windows 10 (clean install from windows 7) my hotkeys have been working very unreliably. I have shortcuts for monitor profiles as well as a shortcut for changing audio output. Sometimes no shortcuts work and sometimes some will work and others wont. I thought this might have been an issue with my PC going to sleep but have noticed this issue on fresh boots too. Tried reinstalling displayfusion but cant seem to solve it. Any help would be appreciated!

Now that you mention it, im having this issue aswell, but it seems like its only for 1 of my monitor profiles (the other one works virtually every time i hit it)

same as you 10240

10240 as well

EDIT: Just updated to 10586. Will give it a whirl and post back in a couple days, but if you say there were problems in the 10240 build then I'm sure this update should help, so thanks! Didn't realize windows wasnt updating automatically.