I have a BENQ GW2765 as my second monitor and my Dell XPS13 display as my primary.

Previously I was running the monitor over a DisplayPort connection and DisplayFusion worked fine. However, many monitors have a DisplayPort problem in that occasionally an internal capacitor causes the monitor to fail to recognize a signal and you have to unplug the thing for several minutes. Very annoying, so I switched to HDMI.

I had to tweak the setup a little for HDMI (DisplayPort was 59Hz, HDMI is 60Hz) so that profile was saved over after I switched.

Now upon power-up (or wake-up), I get the secondary monitor wallpaper, my laptop screen is blank, and all my icons and taskbar jumps to the second monitor. I have to manually tell DF to load the profile which fixes the displays and moves my taskbar back to my primary (laptop) screen, then I have to manually load the icon positions.

It sort of recognizes the profile, I guess, because the secondary screen is showing the correct wallpaper.

Oh and the Windows login screen starts out on the secondary, whereas under DisplayPort it started on my laptop and the secondary was blank.

This is Win 10 Pro with Start10.

I wondered what would happen if I woke up the laptop with the HDMI disconnected, then connected after login.

It recognizes the laptop-only profile, of course. This seems to happen pretty slowly. When I plug in the HDMI, the laptop's screen goes blank and everything moves to the secondary display. It reproduces the laptop wallpaper up there. Here again I have to reload the multi-monitor profile, although in this case it also automatically loads the icons.

Even though all my monitor profiles are set to not change the audio output, it also switches me to HDMI audio every time.

I haven't had time yet to try your suggestion, but notice in the scenario in my second post I am already logged in and DF still doesn't seem to recognize the change from laptop only to HDMI multi-monitor...

I don't understand. When I plug in at the office it switches to that profile... I'd say "or maybe Windows is doing that" except that it restores my icon layout properly too, and we all know Microsoft has ignored that problem for almost 20 years!