@Keith: It had no effect on my issue. It seems to me it must be recent changes that caused the issue, and it seems to be linked to the monitor identity numbers. When my TV is turned on, it automatically becomes the monitor with Identity #1, and the "Primary Monitor" is switched to Identity #2.
So Profile 1 is set to the following image
And Profile 2 is set to this image
When I turn the TV on and Switch to Profile 2, everything is fine, but it refuses to switch back to Profile 1 and I have to set it up manually all over again.
This is what Profile 1 looks like when the TV is turned off, but it obviously doesn't recognize the profile which is fine, it should only recognize it when the TV is on.
So when either the computer or TV is turned off, Display Fusion is forgetting Profile 1 for some reason, and when I try to select it, it jumbles my monitors up, having it extend to the TV, or having just the TV turn on, or sometimes just the "Primary Monitor".