Every time I update the NVidia drivers on my Windows 10 Pro computer my wallpapers settings seem to get lost. I have 2 monitors with different resolutions and 2 images I chose for them. After a driver update it places the image I chose for my primary display on both. Going to the Display Fusion (free) desktop wallpaper page shows everything to be as it should be, but applying the settings there doesn't change anything. Reboots or even full shutdowns also does not fix the problem.

Well that did seem to work, but what I noticed was another problem. The whole sequence was: I did the latest NVidia graphics driver update, which restarted the computer. After that the wallpapers were as they should be, but the start menu would not popup when left clicked it. This has happened in the past, but I never associated it with DisplayFusion. I restarted the computer again to correct that and the wallpapers were messed up. I tried applying then restarting and it did not work. After that I did what you asked above and the wallpapers are ok now.

So it seems that the problem also is about the Start Menu not working on the primary screen after a graphics update.

Yes, restarting does fix the start menu issue. The strange part is right clicking on the start menu icon seems to be working fine, it is just left clicking to get to the actual start menu after the update that fails.

The problem has returned and none of the above seem to fix it.
- I downloaded and installed the newest NVidia video driver.
- No reboot was needed after the drivers were installed.
- The displays both had the right background on them, but the Start Menu would not come up.
- I rebooted the computer and the Start Menu started to work, but both displays had the primary display background on them.
- I tried reapplying the backgrounds in Display Fusion (DS) and they did not change. I next tried another reboot and they still did not change.
- I tried deleting the transcodedwallpaper file, reapplying the DS settings, and then rebooting and it still did not change.

That is where it stands at the moment - everything seems to be working, except the secondary monitor background is not what I wanted.

NVM answering this as I just decided to go to barebones Win 10 for my monitor backgrounds. I have uninstalled DS and about the only thing I'll miss is the ability to move windows between monitors easily. However if you work for DS you should look into this situation and solve it. Thyanks for the memories!