When creating a new Eyefinity configuration under Windows 10 64-bit with the 16.5.2.1 drivers I am seeing a problem. DisplayFusion does not recognize the Eyefinity configuration and auto-split doesn't do anything.
I'm having another issue with Eyefinity (but unrelated to DisplayFusion). After a reboot the Eyefinity displays are no longer present in Windows. In fact the AMD drivers don't even recognize the card properly. I have to do a DDU uninstall from Safe Mode and re-install to restore normal function. I've contacted AMD about this.
I suspect DisplayFusion isn't at fault!