My problem is with Dark Souls, sometimes when I load the game the shortcuts don't work..

Is there a way to put a custom app in the window management or location boxes to auto turn on Prevent Window activation for this game?

Want to purchase this software but need to make it work first..shortcuts seem to be giving me fits as sometimes it doesnt seem to detect I am pressing them when in a game have to quit game reload and keep trying.

That's because your game hook the key you are pressing, thus preventing DF to get the keys. But I must admit I'd love to have a feature to enable this feature on all fullscreen app or on selected one without a keypress.

Regardless, some game make should simply lock the mouse, like most games do.

This work great, my mouse now stop "ghostly" going to the steam apps on my right window thus making outside click