Been using DF for years, and this is a very recent problem (I'm running DF Pro v9.9 and Windows 10). I have hotkeys to switch between monitor profiles, and when I switch from my 6 monitor profile to my 2 monitor profile, my taskbar (which is set to display only on my center monitor) moves from the left to the top of screen (and I have to manually move it back in taskbar settings).

Haven't noticed it happening during other profile switches. I switch from 2 monitor profile to 6 monitor profile every day and taskbar never moves when I do this profile switch.

Windows taskbar. DF taskbar is disabled.

It also doesn't happen every time I switch from 6 monitor profile to 2 monitor profile, but does happen frequently.

No, I do not. Maybe that will help? I'll try locking the taskbar to see if that stops the taskbar moving when switching DF monitor profiles.