Been a long time user, and this is new oddity.
I always have my 3 monitors, All the same model, left one is in portrait mode. I use a per-monitor background image.
2 are DVI Display ports and one is native HDMI on an HP Elite Desk. (The lil guy)
And I notice coming out of sleep, or taking back control after I have RDP remoted my system, that the screen images are strange torn up collages of all my selected images.
If I go to properties for DF, the image files are right.
If I re-apply the settings, most all the time it repairs.
Sometimes I can simply turn off one monitor and back on, and DF goes through it's gyrations to redraw. (BTW, is that Win 10 behaviors to constantly reconfigure if a monitor shuts off? I can see where it could be really helpful if you change screens with a switcher, but in a static environment I miss the old "nothing moves or blinks, I just fix the monitor.