I'm using a 3 screen setup on Eyefinity, with Windows 8.

When I allow it to auto set the 3 screens in DF, it works pretty well, except when I full screen a DVD (on VLC) or a flash video.

When I do that, it blacks out all three screens, just showing the video in the middle. When I click minimise, the window is now the width of all three screens. If it was a flash video, the flash video goes back to playing in the browser, but sometimes its really messed up, like 2 images of the wrong aspect ratio.